• 221 Main - Restaurant & Cocktail House

    • Food & Drink
    221 Main St.
    St. Joseph, MI 49085
    (269) 982-4000
    • About

      221 Main - Restaurant & Cocktail House is a multi-level venue that combines upscale dining with a casual atmosphere in downtown St. Joe. Guests can indulge in a dinner of steak or seafood in a comfort